Neuropathogenesis of Zika Virus in a Highly Susceptible Immunocompetent Mouse Model after Antibody Blockade of Type I Interferon.

• Main Authors: Darci R Smith (Author), Bradley Hollidge (Author), Sharon Daye (Author), Xiankun Zeng (Author), Candace Blancett (Author), Kyle Kuszpit (Author), Thomas Bocan (Author), Jeff W Koehler (Author), Susan Coyne (Author), Tim Minogue (Author), Tara Kenny (Author), Xiaoli Chi (Author), Soojin Yim (Author), Lynn Miller (Author), Connie Schmaljohn (Author), Sina Bavari (Author), Joseph W Golden (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Animal models are needed to better understand the pathogenic mechanisms of Zika virus (ZIKV) and to evaluate candidate medical countermeasures. Adult mice infected with ZIKV develop a transient viremia, but do not demonstrate signs of morbidity or mortality. Mice deficient in type I or a combination...