Astragalus polysaccharides augment BMSC homing via SDF-1/CXCR4 modulation: a novel approach to counteract peritoneal mesenchymal transformation and fibrosis

• Main Authors: Funing Wang (Author), Huibo Dai (Author), Ziren Zhou (Author), Yun Shan (Author), Manshu Yu (Author), Jinyi Sun (Author), Li Sheng (Author), Liyan Huang (Author), Xiaohui Meng (Author), Yongqing You (Author), Meixiao Sheng (Author)
• Format: Book
• Published: BMC, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Purpose This study aimed to evaluate the potential of astragalus polysaccharide (APS) pretreatment in enhancing the homing and anti-peritoneal fibrosis capabilities of bone marrow mesenchymal stromal cells (BMSCs) and to elucidate the underlying mechanisms. Methods Forty male Sprague-Dawley...