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Discovery of Novel and Highly Potent Inhibitors of SARS CoV-2 Papain-Like Protease Through Structure-Based Pharmacophore Modeling, Virtual Screening, Molecular Docking, Molecular Dynamics Simulations, and Biological Evaluation

Background and Objective: COVID-19 has struck our society as a great calamity, and the need for effective anti-viral drugs is more urgent than ever. Papain-like protease (PLpro) of SARS CoV-2 plays important roles in virus maturation, dysregulation of host inflammation, and antiviral immune response...

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Bibliographic Details
Main Authors:	Xiaoyan Tian (Author), Quanfeng Zhao (Author), Xiaohong Chen (Author), Zhe Peng (Author), Xiaodan Tan (Author), Qin Wang (Author), Lin Chen (Author), Yang Yang (Author)
Format:	Book
Published:	Frontiers Media S.A., 2022-02-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
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