Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component

• Main Authors: Esther J. M. Stoop (Author), Tim Schipper (Author), Sietske K. Rosendahl Huber (Author), Alexander E. Nezhinsky (Author), Fons J. Verbeek (Author), Sudagar S. Gurcha (Author), Gurdyal S. Besra (Author), Christina M. J. E. Vandenbroucke-Grauls (Author), Wilbert Bitter (Author), Astrid M. van der Sar (Author)
• Format: Book
• Published: The Company of Biologists, 2011-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY The hallmark of tuberculosis (TB) is the formation of granulomas, which are clusters of infected macrophages surrounded by additional macrophages, neutrophils and lymphocytes. Although it has long been thought that granulomas are beneficial for the host, there is evidence that mycobacteria a...