A pilot study on developing mucosal vaccine against alveolar echinococcosis (AE) using recombinant tetraspanin 3: Vaccine efficacy and immunology.

• Main Authors: Zhisheng Dang (Author), Kinpei Yagi (Author), Yuzaburo Oku (Author), Hirokazu Kouguchi (Author), Kiichi Kajino (Author), Jun Matsumoto (Author), Ryo Nakao (Author), Hiroyuki Wakaguri (Author), Atsushi Toyoda (Author), Hong Yin (Author), Chihiro Sugimoto (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: We have previously evaluated the vaccine efficacies of seven tetraspanins of Echinococcus multilocularis (Em-TSP1-7) against alveolar echinococcosis (AE) by subcutaneous (s.c.) administration with Freund's adjuvant. Over 85% of liver cyst lesion number reductions (CLNR) were achieve...