Relationship of Intracellular Calcium and Oxygen Radicals to Cisplatin-Related Renal Cell Injury

Abstract.: We investigated the involvement of reactive oxygen species (ROS) and intracellular calcium in nephrotoxicity related to an antitumor agent, cisplatin. In this study, we employed cultured renal epithelial cells (LLC-PK1). Cisplatin at 500 µM significantly increased the production of ROS 5...

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Main Authors: Yoshiko Kawai (Author), Takafumi Nakao (Author), Naoshi Kunimura (Author), Yuka Kohda (Author), Munekazu Gemba (Author)
Format: Book
Published: Elsevier, 2006-01-01T00:00:00Z.
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