Profiling Dopamine-Induced Oxidized Proteoforms of β-synuclein by Top-Down Mass Spectrometry

• Main Authors: Arianna Luise (Author), Elena De Cecco (Author), Erika Ponzini (Author), Martina Sollazzo (Author), PierLuigi Mauri (Author), Frank Sobott (Author), Giuseppe Legname (Author), Rita Grandori (Author), Carlo Santambrogio (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The formation of multiple proteoforms by post-translational modifications (PTMs) enables a single protein to acquire distinct functional roles in its biological context. Oxidation of methionine residues (Met) is a common PTM, involved in physiological (e.g., signaling) and pathological (e.g., oxidat...