Reducing cell intrinsic immunity to mRNA vaccine alters adaptive immune responses in mice

• Main Authors: Ziyin Wang (Author), Egon J. Jacobus (Author), David C. Stirling (Author), Stefanie Krumm (Author), Katie E. Flight (Author), Robert F. Cunliffe (Author), Jonathan Mottl (Author), Charanjit Singh (Author), Lucy G. Mosscrop (Author), Leticia Aragão Santiago (Author), Annette B. Vogel (Author), Katalin Kariko (Author), Ugur Sahin (Author), Stephanie Erbar (Author), John S. Tregoning (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The response to mRNA vaccines needs to be sufficient for immune cell activation and recruitment, but moderate enough to ensure efficacious antigen expression. The choice of the cap structure and use of N1-methylpseudouridine (m1Ψ) instead of uridine, which have been shown to reduce RNA sensing by th...