Reducing cell intrinsic immunity to mRNA vaccine alters adaptive immune responses in mice

The response to mRNA vaccines needs to be sufficient for immune cell activation and recruitment, but moderate enough to ensure efficacious antigen expression. The choice of the cap structure and use of N1-methylpseudouridine (m1Ψ) instead of uridine, which have been shown to reduce RNA sensing by th...

Full description

Saved in:
Bibliographic Details
Main Authors: Ziyin Wang (Author), Egon J. Jacobus (Author), David C. Stirling (Author), Stefanie Krumm (Author), Katie E. Flight (Author), Robert F. Cunliffe (Author), Jonathan Mottl (Author), Charanjit Singh (Author), Lucy G. Mosscrop (Author), Leticia Aragão Santiago (Author), Annette B. Vogel (Author), Katalin Kariko (Author), Ugur Sahin (Author), Stephanie Erbar (Author), John S. Tregoning (Author)
Format: Book
Published: Elsevier, 2023-12-01T00:00:00Z.
Subjects:
Online Access:Connect to this object online.
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

Connect to this object online.

3rd Floor Main Library

Holdings details from 3rd Floor Main Library
Call Number: A1234.567
Copy 1 Available