CDR loop interactions can determine heavy and light chain pairing preferences in bispecific antibodies

• Main Authors: Monica L. Fernández-Quintero (Author), Katharina B. Kroell (Author), Lukas J. Grunewald (Author), Anna-Lena M. Fischer (Author), Jakob R. Riccabona (Author), Klaus R. Liedl (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

As the current biotherapeutic market is dominated by antibodies, the design of different antibody formats, like bispecific antibodies, is critical to the advancement of the field. In contrast to monovalent antibodies, which consist of two identical antigen-binding sites, bispecific antibodies can ta...