Complexes of Ibuprofen Thiazolidin-4-One Derivatives with β-Cyclodextrin: Characterization and In Vivo Release Profile and Biological Evaluation

• Main Authors: Ioana Mirela Vasincu (Author), Maria Apotrosoaei (Author), Florentina Lupascu (Author), Andreea-Teodora Iacob (Author), Simona-Eliza Giusca (Author), Irina-Draga Caruntu (Author), Narcisa-Laura Marangoci (Author), Anca Roxana Petrovici (Author), Gabriela Dumitrita Stanciu (Author), Bogdan-Ionel Tamba (Author), Bianca-Stefania Profire (Author), Alin-Viorel Focsa (Author), Mariana Pinteala (Author), Lenuta Profire (Author)
• Format: Book
• Published: MDPI AG, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Generally, NSAIDs are weakly soluble in water and contain both hydrophilic and hydrophobic groups. One of the most widely used NSAIDs is ibuprofen, which has a poor solubility and high permeability profile. By creating dynamic, non-covalent, water-soluble inclusion complexes, cyclodextrins (CDs) can...