ISG15 overexpression compensates the defect of Crimean-Congo hemorrhagic fever virus polymerase bearing a protease-inactive ovarian tumor domain.

Crimean-Congo Hemorrhagic Fever virus (CCHFV; family Nairoviridae) is an extremely pathogenic member of the Bunyavirales order. Previous studies have shown that the N-terminal domain of the CCHFV polymerase (L) contains an ovarian tumor-type protease (OTU) domain with the capability to remove both u...

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Main Authors: Stephanie Devignot (Author), Thilo Kromer (Author), Ali Mirazimi (Author), Friedemann Weber (Author)
Format: Book
Published: Public Library of Science (PLoS), 2020-09-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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