An unbiased seed-based RNAi selection screen identifies small RNAs that inhibit androgen signaling and prostate cancer cell growth

• Main Authors: Joshua M. Corbin (Author), Constantin Georgescu (Author), Lin Wang (Author), Jonathan D. Wren (Author), Magdalena Bieniasz (Author), Chao Xu (Author), Adam S. Asch (Author), Maria J. Ruiz Echevarría (Author)
• Format: Book
• Published: Elsevier, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Blocking androgen receptor signaling is the mainstay of therapy for advanced prostate cancer (PCa). However, acquired resistance to single agents targeting this pathway results in the development of lethal castration-resistant PCa. Combination therapy approaches represent a promising strategy for th...