Development and Characterization of Eudragit^®-Based Electrospun Nanofibrous Mats and Their Formulation into Nanofiber Tablets for the Modified Release of Furosemide

• Main Authors: Marilena Vlachou (Author), Stefanos Kikionis (Author), Angeliki Siamidi (Author), Sotiria Kyriakou (Author), Andrew Tsotinis (Author), Efstathia Ioannou (Author), Vassilios Roussis (Author)
• Format: Book
• Published: MDPI AG, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Furosemide, a chloride channel blocker ordinarily used as a high-ceiling or loop diuretic, is practically insoluble in water and dilute acids. Due to its acidic nature, furosemide is mostly absorbed in the stomach and in the upper small intestine. Efforts have focused on the development of sustained...