Evaluation of in vitro transdermal permeation, mass spectrometric imaging, and in vivo analgesic effects of pregabalin using a pluronic lecithin organogel formulation in mice

• المؤلفون الرئيسيون: Michiru Nagao (مؤلف), Masataka Tajima (مؤلف), Erika Sugiyama (مؤلف), Ryosuke Shinouchi (مؤلف), Keita Shibata (مؤلف), Masayuki Yoshikawa (مؤلف), Takushi Yamamoto (مؤلف), Vilasinee Hirunpanich Sato (مؤلف), Koji Nobe (مؤلف), Hitoshi Sato (مؤلف)
• التنسيق: كتاب
• منشور في: Wiley, 2022-04-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Abstract In clinical practice, pregabalin is orally administered for neuropathic pain, but causes severe central nervous system side effects, such as dizziness, which results in dose limitation or discontinuation. To reduce the central side effects of pregabalin, we developed four pregabalin prepara...