Evaluation of in vitro transdermal permeation, mass spectrometric imaging, and in vivo analgesic effects of pregabalin using a pluronic lecithin organogel formulation in mice

• Main Authors: Michiru Nagao (Author), Masataka Tajima (Author), Erika Sugiyama (Author), Ryosuke Shinouchi (Author), Keita Shibata (Author), Masayuki Yoshikawa (Author), Takushi Yamamoto (Author), Vilasinee Hirunpanich Sato (Author), Koji Nobe (Author), Hitoshi Sato (Author)
• Format: Book
• Published: Wiley, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract In clinical practice, pregabalin is orally administered for neuropathic pain, but causes severe central nervous system side effects, such as dizziness, which results in dose limitation or discontinuation. To reduce the central side effects of pregabalin, we developed four pregabalin prepara...