Amiodarone reduces depolarization-evoked glutamate release from hippocampual synaptosomes

• Main Authors: Chia Yu Chang (Author), Chi Feng Hung (Author), Shu Kuei Huang (Author), Jinn Rung Kuo (Author), Su Jane Wang (Author)
• 格式: 图书
• 出版: Elsevier, 2017-03-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Decreased brain glutamate level has emerged as a new therapeutic approach for epilepsy. This study investigated the effect and mechanism of amiodarone, an anti-arrhythmic drug with antiepileptic activity, on glutamate release in the rat hippocampus. In a synaptosomal preparation, amiodarone reduced...