Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing

• Main Authors: Brian Y.H. Lam (Author), Irene Cimino (Author), Joseph Polex-Wolf (Author), Sara Nicole Kohnke (Author), Debra Rimmington (Author), Valentine Iyemere (Author), Nicholas Heeley (Author), Chiara Cossetti (Author), Reiner Schulte (Author), Luis R. Saraiva (Author), Darren W. Logan (Author), Clemence Blouet (Author), Stephen O'Rahilly (Author), Anthony P. Coll (Author), Giles S.H. Yeo (Author)
• Format: Book
• Published: Elsevier, 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Arcuate proopiomelanocortin (POMC) neurons are critical nodes in the control of body weight. Often characterized simply as direct targets for leptin, recent data suggest a more complex architecture. Methods: Using single cell RNA sequencing, we have generated an atlas of gene expression i...