The liver plays a major role in clearance and destruction of blood trypomastigotes in Trypanosoma cruzi chronically infected mice.

• Main Authors: Luiz Roberto Sardinha (Author), Tainá Mosca (Author), Rosa Maria Elias (Author), Rogério Silva do Nascimento (Author), Lígia A Gonçalves (Author), Daniella Zanetti Bucci (Author), Cláudio Romero Farias Marinho (Author), Carlos Penha-Gonçalves (Author), Maria Regina D'Império Lima (Author), José Maria Alvarez (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Intravenous challenge with Trypanosoma cruzi can be used to investigate the process and consequences of blood parasite clearance in experimental Chagas disease. One hour after intravenous challenge of chronically infected mice with 5x10(6) trypomastigotes, the liver constituted a major site of paras...