Identification of Potential RBPJ-Specific Inhibitors for Blocking Notch Signaling in Breast Cancer Using a Drug Repurposing Strategy

• Main Authors: Mengjie Rui (Author), Min Cai (Author), Yu Zhou (Author), Wen Zhang (Author), Lianglai Gao (Author), Ke Mi (Author), Wei Ji (Author), Dan Wang (Author), Chunlai Feng (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Notch signaling is a key parameter in regulating cell fate during tissue homeostasis, and an aberrant Notch pathway can result in mammary gland carcinoma and has been associated with poor breast cancer diagnosis. Although inhibiting Notch signaling would be advantageous in the treatment of breast ca...