High-altitude Hypoxia Influences the Activities of the Drug-Metabolizing Enzyme CYP3A1 and the Pharmacokinetics of Four Cardiovascular System Drugs

• Main Authors: Junbo Zhu (Author), Yabin Duan (Author), Delong Duo (Author), Jianxin Yang (Author), Xue Bai (Author), Guiqin Liu (Author), Qian Wang (Author), Xuejun Wang (Author), Ning Qu (Author), Yang Zhou (Author), Xiangyang Li (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

(1) Background: High-altitude hypoxia has been shown to affect the pharmacokinetic properties of drugs. Although there is a high incidence of cardiovascular disease among individuals living in high-altitude areas, studies on the effect of high-altitude hypoxia on the pharmacokinetic properties of ca...