Aging-elevated inflammation promotes DNMT3A R878H-driven clonal hematopoiesis

• Main Authors: Min Liao (Author), Ruiqing Chen (Author), Yang Yang (Author), Hanqing He (Author), Liqian Xu (Author), Yuxuan Jiang (Author), Zhenxing Guo (Author), Wei He (Author), Hong Jiang (Author), Jianwei Wang (Author)
• Format: Book
• Published: Elsevier, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aging-elevated DNMT3A R882H-driven clonal hematopoiesis (CH) is a risk factor for myeloid malignancies remission and overall survival. Although some studies were conducted to investigate this phenomenon, the exact mechanism is still under debate. In this study, we observed that DNMT3A R878H bone mar...