Fibroblasts in Head and Neck Squamous Cell Carcinoma Associated With Perineural Invasion Have High-Level Nuclear Yes-Associated Protein (YAP) Expression

• Main Authors: Yanghua Wang MD, PhD (Author), Adam Gersten MD (Author), Susana Moleirinho PhD (Author), Frank J. Gunn-Moore PhD (Author), Paul A. Reynolds PhD (Author), Michael B. Prystowsky MD, PhD (Author)
• Format: Book
• Published: Elsevier, 2015-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We retrospectively studied the expression of Yes-associated protein (YAP) using immunohistochemical staining in 10 cases of head and neck squamous cell carcinoma with associated perineural invasion. We find that fibroblasts in areas associated with perineural invasion show higher levels of nuclear Y...