The Neuroactive Steroid Pregnanolone Glutamate: Anticonvulsant Effect, Metabolites and Its Effect on Neurosteroid Levels in Developing Rat Brains

• Main Authors: Eva Kudova (Author), Pavel Mares (Author), Martin Hill (Author), Katerina Vondrakova (Author), Grygoriy Tsenov (Author), Hana Chodounska (Author), Hana Kubova (Author), Karel Vales (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pregnanolone glutamate (PA-G) is a neuroactive steroid that has been previously demonstrated to be a potent neuroprotective compound in several biological models in vivo. Our in vitro experiments identified PA-G as an inhibitor of <i>N</i>-methyl-<i>D</i>-aspartate receptors...