Prostaglandin E𝟐 and the Suppression of Phagocyte Innate Immune Responses in Different Organs

• Main Authors: Alexandra Medeiros (Author), Camila Peres-Buzalaf (Author), Felipe Fortino Verdan (Author), C. Henrique Serezani (Author)
• Format: Book
• Published: Hindawi Limited, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The local and systemic production of prostaglandin E2 (PGE2) and its actions in phagocytes lead to immunosuppressive conditions. PGE2 is produced at high levels during inflammation, and its suppressive effects are caused by the ligation of the E prostanoid receptors EP2 and EP4, which results in the...