Click chemistry based synthesis, cytotoxic activity and molecular docking of novel triazole-thienopyrimidine hybrid glycosides targeting EGFR

• Main Authors: Reham R. Khattab (Author), Asma K. Alshamari (Author), Allam A. Hassan (Author), Hussein H. Elganzory (Author), Wael A. El-Sayed (Author), Hanem M. Awad (Author), Eman S. Nossier (Author), Nasser A. Hassan (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the current study, new thienopyrimidine conjugates bearing 1,2,3-triazole core and different sugar moieties have been designed and synthesized by Cu(I)-catalysed click dipolar cycloaddition. The cytotoxic activity of the synthesised conjugates 2, 5, 7, and 13-18 was studied against HCT-116 and MC...