Click chemistry based synthesis, cytotoxic activity and molecular docking of novel triazole-thienopyrimidine hybrid glycosides targeting EGFR

• Egile Nagusiak: Reham R. Khattab (Egilea), Asma K. Alshamari (Egilea), Allam A. Hassan (Egilea), Hussein H. Elganzory (Egilea), Wael A. El-Sayed (Egilea), Hanem M. Awad (Egilea), Eman S. Nossier (Egilea), Nasser A. Hassan (Egilea)
• Formatua: Liburua
• Argitaratua: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

In the current study, new thienopyrimidine conjugates bearing 1,2,3-triazole core and different sugar moieties have been designed and synthesized by Cu(I)-catalysed click dipolar cycloaddition. The cytotoxic activity of the synthesised conjugates 2, 5, 7, and 13-18 was studied against HCT-116 and MC...