Anti-Sporothrix brasiliensis activity of different pyrazinoic acid prodrugs: a repurposing evaluation

• Main Authors: Stefanie Bressan Waller (Author), Ceres Nakasu (Author), Anna Luiza Silva (Author), Renata Osório de Faria (Author), João Paulo dos Santos Fernandes (Author), Marlete Brum Cleff (Author)
• Format: Book
• Published: Universidade de São Paulo, 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

From drug repurposing studies, this work aimed to evaluate the activity of different pyrazinoic acid (POA) derivatives against Sporothrix brasiliensis. The POA esters were prepared and characterized as previously reported by classical esterification reactions, with good to excellent yields. Sporothr...