Pathophysiology of Mitochondrial Dysfunction in Human Spermatozoa: Focus on Energetic Metabolism, Oxidative Stress and Apoptosis

• Main Authors: Chiara Castellini (Author), Settimio D'Andrea (Author), Giuliana Cordeschi (Author), Maria Totaro (Author), Antonio Parisi (Author), Giovanna Di Emidio (Author), Carla Tatone (Author), Sandro Francavilla (Author), Arcangelo Barbonetti (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The dogma of mitochondria as the major source of energy in supporting sperm motility should be critically reconsidered in the light of several experimental data pointing to a major role of glycolysis in mammalian spermatozoa. In this light, the reported positive correlation between the mitochondrial...