The Combination of MBP and BCG-Induced Dendritic Cell Maturation through TLR2/TLR4 Promotes Th1 Activation In Vitro and Vivo

• Main Authors: LiNa Jiang (Author), GuoMu Liu (Author), WeiHua Ni (Author), NanNan Zhang (Author), Jing Jie (Author), Fei Xie (Author), GuiXiang Tai (Author)
• Formato: Livro
• Publicado em: Hindawi Limited, 2017-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

To explore whether TLR2/TLR4 could be involved in the maturation of dendritic cells and polarization of CD4+ T cells induced by dendritic cells stimulated with MBP and BCG, in vitro and in vivo experiments using TLR2−/− or TLR4−/− mice were employed. MBP and BCG elevated CD80, CD86 and MHC class II...