Ectopic expression of NKG7 enhances CAR-T function and improves the therapeutic efficacy in liquid and solid tumors

• Main Authors: Yuxin Chen (Author), Meng Wang (Author), Shuxin Huang (Author), Lulu Han (Author), Ying Cai (Author), Xiaodi Xu (Author), Shuwen Sun (Author), Zhaokai Chen (Author), Junze Chen (Author), Jiatian Yu (Author), Hongwei Du (Author), Huizhong Li (Author), Junnian Zheng (Author), Bo Ma (Author), Gang Wang (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lack of biopsies after treatment, especially in solid tumors, restricts the understanding of chimeric antigen receptor (CAR)-T cells -related characteristic in vivo, thus hindering the development of strategies to improve CAR-T cells efficacy. Here, we applied nineteen individual single-cell RNA seq...