Antagonistic epistasis of Hnf4α and FoxO1 metabolic networks through enhancer interactions in β-cell function

• Main Authors: Taiyi Kuo (Author), Wen Du (Author), Yasutaka Miyachi (Author), Prasanna K. Dadi (Author), David A. Jacobson (Author), Daniel Segrè (Author), Domenico Accili (Author)
• Format: Book
• Published: Elsevier, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Genetic and acquired abnormalities contribute to pancreatic β-cell failure in diabetes. Transcription factors Hnf4α (MODY1) and FoxO1 are respective examples of these two components and act through β-cell-specific enhancers. However, their relationship is unclear. Methods: In this report,...