Omiganan Enhances Imiquimod‐Induced Inflammatory Responses in Skin of Healthy Volunteers

• Main Authors: Tessa Niemeyer‐van der Kolk (Author), Salma Assil (Author), Thomas P. Buters (Author), Melanie Rijsbergen (Author), Erica S. Klaassen (Author), Gary Feiss (Author), Edwin Florencia (Author), Errol P. Prens (Author), Jacobus Burggraaf (Author), Martijn B.A. vanDoorn (Author), Robert Rissmann (Author), Matthijs Moerland (Author)
• Format: Book
• Published: Wiley, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Omiganan (OMN; a synthetic cationic peptide) and imiquimod (IMQ; a TLR7 agonist) have synergistic effects on interferon responses in vitro. The objective of this study was to translate this to a human model for proof‐of‐concept, and to explore the potential of OMN add‐on treatment for viral skin dis...