Diabetic polyneuropathy, sensory neurons, nuclear structure and spliceosome alterations: a role for CWC22

• Główni autorzy: Masaki Kobayashi (Autor), Ambika Chandrasekhar (Autor), Chu Cheng (Autor), Jose A. Martinez (Autor), Hilarie Ng (Autor), Cristiane de la Hoz (Autor), Douglas W. Zochodne (Autor)
• Format: Książka
• Wydane: The Company of Biologists, 2017-03-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Unique deficits in the function of adult sensory neurons as part of their early neurodegeneration might account for progressive polyneuropathy during chronic diabetes mellitus. Here, we provide structural and functional evidence for aberrant pre-mRNA splicing in a chronic type 1 model of experimenta...