Diabetic polyneuropathy, sensory neurons, nuclear structure and spliceosome alterations: a role for CWC22

• Main Authors: Masaki Kobayashi (Author), Ambika Chandrasekhar (Author), Chu Cheng (Author), Jose A. Martinez (Author), Hilarie Ng (Author), Cristiane de la Hoz (Author), Douglas W. Zochodne (Author)
• Format: Book
• Published: The Company of Biologists, 2017-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Unique deficits in the function of adult sensory neurons as part of their early neurodegeneration might account for progressive polyneuropathy during chronic diabetes mellitus. Here, we provide structural and functional evidence for aberrant pre-mRNA splicing in a chronic type 1 model of experimenta...