Small Molecule Cjoc42 Improves Chemo-Sensitivity and Increases Levels of Tumor Suppressor Proteins in Hepatoblastoma Cells and in Mice by Inhibiting Oncogene Gankyrin

• Príomhchruthaitheoirí: Amber M. D'Souza (Údar), Ashley Cast (Údar), Meenasri Kumbaji (Údar), Maria Rivas (Údar), Ruhi Gulati (Údar), Michael Johnston (Údar), David Smithrud (Údar), James Geller (Údar), Nikolai Timchenko (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

Objective: Relapsed hepatoblastoma (HBL) and upfront hepatocellular carcinoma (HCC) are notoriously chemoresistant tumors associated with poor outcomes. Gankyrin (Gank) is a known oncogene that is overexpressed in pediatric liver cancer and implicated in chemo-resistance. The goal of this study was...