Small Molecule Cjoc42 Improves Chemo-Sensitivity and Increases Levels of Tumor Suppressor Proteins in Hepatoblastoma Cells and in Mice by Inhibiting Oncogene Gankyrin

• Главные авторы: Amber M. D'Souza (Автор), Ashley Cast (Автор), Meenasri Kumbaji (Автор), Maria Rivas (Автор), Ruhi Gulati (Автор), Michael Johnston (Автор), David Smithrud (Автор), James Geller (Автор), Nikolai Timchenko (Автор)
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• Опубликовано: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• Предметы: article
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Objective: Relapsed hepatoblastoma (HBL) and upfront hepatocellular carcinoma (HCC) are notoriously chemoresistant tumors associated with poor outcomes. Gankyrin (Gank) is a known oncogene that is overexpressed in pediatric liver cancer and implicated in chemo-resistance. The goal of this study was...