Human UDP-Glucuronosyltransferase 2B4 and 2B7 Are Responsible for Naftopidil Glucuronidation in Vitro

• Príomhchruthaitheoirí: Xia-Wen Liu (Údar), Yi Rong (Údar), Xing-Fei Zhang (Údar), Jun-Jun Huang (Údar), Yi Cai (Údar), Bi-Yun Huang (Údar), Liu Zhu (Údar), Bo Wu (Údar), Ning Hou (Údar), Cheng-Feng Luo (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: Frontiers Media S.A., 2018-01-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

Naftopidil (NAF) is widely used for the treatment of benign prostatic hyperplasia and prevention of prostate cancer in elderly men. These patients receive a combination of drugs, which involves high risk for drug-drug interaction. NAF exhibits superior efficacy but must be administered at a much hig...