Human UDP-Glucuronosyltransferase 2B4 and 2B7 Are Responsible for Naftopidil Glucuronidation in Vitro

• Main Authors: Xia-Wen Liu (Author), Yi Rong (Author), Xing-Fei Zhang (Author), Jun-Jun Huang (Author), Yi Cai (Author), Bi-Yun Huang (Author), Liu Zhu (Author), Bo Wu (Author), Ning Hou (Author), Cheng-Feng Luo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Naftopidil (NAF) is widely used for the treatment of benign prostatic hyperplasia and prevention of prostate cancer in elderly men. These patients receive a combination of drugs, which involves high risk for drug-drug interaction. NAF exhibits superior efficacy but must be administered at a much hig...