Contribution of Neurons and Glial Cells to Complement-Mediated Synapse Removal during Development, Aging and in Alzheimer's Disease

• Κύριοι συγγραφείς: Celia Luchena (Συγγραφέας), Jone Zuazo-Ibarra (Συγγραφέας), Elena Alberdi (Συγγραφέας), Carlos Matute (Συγγραφέας), Estibaliz Capetillo-Zarate (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Hindawi Limited, 2018-01-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Synapse loss is an early manifestation of pathology in Alzheimer's disease (AD) and is currently the best correlate to cognitive decline. Microglial cells are involved in synapse pruning during development via the complement pathway. Moreover, recent evidence points towards a key role played by...