Paroxetine prevented the down-regulation of astrocytic L-Glu transporters in neuroinflammation

• Main Authors: Koki Fujimori (Author), Junpei Takaki (Author), Yukari Shigemoto-Mogami (Author), Yuko Sekino (Author), Takeshi Suzuki (Author), Kaoru Sato (Author)
• Format: Book
• Published: Elsevier, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The extracellular L-glutamate (L-Glu) concentration is elevated in neuroinflammation, thereby causing excitotoxicity. One of the mechanisms is down-regulation of astrocyte L-Glu transporters. Some antidepressants have anti-inflammatory effects. We therefore investigated effects of various antidepres...