Empagliflozin Reduces Renal Hyperfiltration in Response to Uninephrectomy, but Is Not Nephroprotective in UNx/DOCA/Salt Mouse Models

• Main Authors: Philipp Tauber (Author), Frederick Sinha (Author), Raffaela S. Berger (Author), Wolfram Gronwald (Author), Katja Dettmer (Author), Michaela Kuhn (Author), Maximilian Trum (Author), Lars S. Maier (Author), Stefan Wagner (Author), Frank Schweda (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Large-scale clinical outcome studies demonstrated the efficacy of SGLT2 inhibitors in patients with type II diabetes. Besides their therapeutic efficacy in diabetes, significant renoprotection was observed in non-diabetic patients with chronic kidney disease (CKD), suggesting the existence of glucos...