44Sc for labeling of DOTA- and NODAGA-functionalized peptides: preclinical in vitro and in vivo investigations

• Main Authors: Katharina A. Domnanich (Author), Cristina Müller (Author), Renata Farkas (Author), Raffaella M. Schmid (Author), Bernard Ponsard (Author), Roger Schibli (Author), Andreas Türler (Author), Nicholas P. van der Meulen (Author)
• Format: Book
• Published: SpringerOpen, 2016-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Recently, 44Sc (T1/2 = 3.97 h, Eβ+ av = 632 keV, I = 94.3 %) has emerged as an attractive radiometal candidate for PET imaging using DOTA-functionalized biomolecules. The aim of this study was to investigate the potential of using NODAGA for the coordination of 44Sc. Two pairs of...