Targeting transgenic proteins to alpha granules for platelet-directed gene therapy

• Egile Nagusiak: Vanessa M.A. Woods (Egilea), Lisette J. Latorre-Rey (Egilea), Franziska Schenk (Egilea), Marcel G.E. Rommel (Egilea), Thomas Moritz (Egilea), Ute Modlich (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2022-03-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Platelets are anucleate blood cells that are shed from megakaryocytes (MKs) into the bloodstream to maintain hemostasis and promote wound healing after vascular injury. To carry out their functions, platelets become activated and release bioactive substances from their secretory granules. As alpha g...