Targeting transgenic proteins to alpha granules for platelet-directed gene therapy

• Main Authors: Vanessa M.A. Woods (Author), Lisette J. Latorre-Rey (Author), Franziska Schenk (Author), Marcel G.E. Rommel (Author), Thomas Moritz (Author), Ute Modlich (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Platelets are anucleate blood cells that are shed from megakaryocytes (MKs) into the bloodstream to maintain hemostasis and promote wound healing after vascular injury. To carry out their functions, platelets become activated and release bioactive substances from their secretory granules. As alpha g...