Mucoadhesive buccal film of almotriptan improved therapeutic delivery in rabbit model

• Main Authors: Anroop B. Nair (Author), Bandar E. Al-Dhubiab (Author), Jigar Shah (Author), Shery Jacob (Author), Vismay Saraiya (Author), Mahesh Attimarad (Author), Nagaraja SreeHarsha (Author), Sabah H. Akrawi (Author), Tamer M. Shehata (Author)
• Format: Book
• Published: Elsevier, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Administration of almotriptan as an oral therapy is largely limited because of poor aqueous solubility and rather low bioavailability. The aim of present investigation was to formulate oral mucoadhesive film of almotriptan to improve the drug delivery and desired therapeutic effects. Placebo films (...