KR-31761, a Novel K+ATP-Channel Opener, Exerts Cardioprotective Effects by Opening Both Mitochondrial K+ATP and Sarcolemmal K+ATP Channels in Rat Models of Ischemia/Reperfusion-Induced Heart Injury

• Main Authors: Min-Kyu Yang (Author), Sung-Hun Lee (Author), Ho-Won Seo (Author), Kyu-Yang Yi (Author), Sung-Eun Yoo (Author), Byung-Ho Lee (Author), Hun-Jong Chung (Author), Hyung-Sik Won (Author), Chang-Soo Lee (Author), Suk-Hyung Kwon (Author), Wahn-Soo Choi (Author), Hwa-Sup Shin (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The cardioprotective effects of KR-31761, a newly synthesized K+ATP opener, were evaluated in rat models of ischemia/reperfusion (I/R) heart injury. In isolated rat hearts subjected to 30-min global ischemia/30-min reperfusion, KR-31761 perfused prior to ischemia significantly increased both the lef...