STAT3 Gene Silencing by Aptamer-siRNA Chimera as Selective Therapeutic for Glioblastoma

• मुख्य लेखकों: Carla Lucia Esposito (लेखक), Silvia Nuzzo (लेखक), Silvia Catuogno (लेखक), Simona Romano (लेखक), Filomena de Nigris (लेखक), Vittorio de Franciscis (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2018-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Glioblastoma (GBM) is the most frequent and aggressive primary brain tumor in adults, and despite advances in neuro-oncology, the prognosis for patients remains dismal. The signal transducer and activator of transcription-3 (STAT3) has been reported as a key regulator of the highly aggressive mesenc...