Beneficial Effect of Phenytoin and Carbamazepine on GFAP Gene Expression and Mutant GFAP Folding in a Cellular Model of Alexander's Disease

• Автори: Tiziana Bachetti (Автор), Eleonora Di Zanni (Автор), Annalisa Adamo (Автор), Francesca Rosamilia (Автор), M. Margherita Sechi (Автор), Paolo Solla (Автор), Matteo Bozzo (Автор), Isabella Ceccherini (Автор), GianPietro Sechi (Автор)
• Формат: Книга
• Опубліковано: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Alexander's disease (AxD) is a rare, usually relentlessly progressive disorder of astroglial cells in the central nervous system related to mutations in the gene encoding the type III intermediate filament protein, glial fibrillary acidic protein (GFAP). The pathophysiology of AxD is only parti...