Beneficial Effect of Phenytoin and Carbamazepine on GFAP Gene Expression and Mutant GFAP Folding in a Cellular Model of Alexander's Disease

• मुख्य लेखकों: Tiziana Bachetti (लेखक), Eleonora Di Zanni (लेखक), Annalisa Adamo (लेखक), Francesca Rosamilia (लेखक), M. Margherita Sechi (लेखक), Paolo Solla (लेखक), Matteo Bozzo (लेखक), Isabella Ceccherini (लेखक), GianPietro Sechi (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Alexander's disease (AxD) is a rare, usually relentlessly progressive disorder of astroglial cells in the central nervous system related to mutations in the gene encoding the type III intermediate filament protein, glial fibrillary acidic protein (GFAP). The pathophysiology of AxD is only parti...