Beneficial Effect of Phenytoin and Carbamazepine on GFAP Gene Expression and Mutant GFAP Folding in a Cellular Model of Alexander's Disease

• Main Authors: Tiziana Bachetti (Author), Eleonora Di Zanni (Author), Annalisa Adamo (Author), Francesca Rosamilia (Author), M. Margherita Sechi (Author), Paolo Solla (Author), Matteo Bozzo (Author), Isabella Ceccherini (Author), GianPietro Sechi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alexander's disease (AxD) is a rare, usually relentlessly progressive disorder of astroglial cells in the central nervous system related to mutations in the gene encoding the type III intermediate filament protein, glial fibrillary acidic protein (GFAP). The pathophysiology of AxD is only parti...