1,3,4-Oxadiazole-naphthalene hybrids as potential VEGFR-2 inhibitors: design, synthesis, antiproliferative activity, apoptotic effect, and in silico studies

• Главные авторы: Mohamed Hagras (Автор), Marwa A. Saleh (Автор), Rogy R. Ezz Eldin (Автор), Abdelrahman A. Abuelkhir (Автор), Emad Gamil Khidr (Автор), Ahmed A. El-Husseiny (Автор), Hesham A. El-Mahdy (Автор), Eslam B. Elkaeed (Автор), Ibrahim H. Eissa (Автор)
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• Опубликовано: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Предметы: article
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In the current work, some 1,3,4-oxadiazole-naphthalene hybrids were designed and synthesised as VEGFR-2 inhibitors. The synthesised compounds were evaluated in vitro for their antiproliferative activity against two human cancer cell lines namely, HepG-2 and MCF-7. Compounds that exhibited promising...