1,3,4-Oxadiazole-naphthalene hybrids as potential VEGFR-2 inhibitors: design, synthesis, antiproliferative activity, apoptotic effect, and in silico studies

• Main Authors: Mohamed Hagras (Author), Marwa A. Saleh (Author), Rogy R. Ezz Eldin (Author), Abdelrahman A. Abuelkhir (Author), Emad Gamil Khidr (Author), Ahmed A. El-Husseiny (Author), Hesham A. El-Mahdy (Author), Eslam B. Elkaeed (Author), Ibrahim H. Eissa (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the current work, some 1,3,4-oxadiazole-naphthalene hybrids were designed and synthesised as VEGFR-2 inhibitors. The synthesised compounds were evaluated in vitro for their antiproliferative activity against two human cancer cell lines namely, HepG-2 and MCF-7. Compounds that exhibited promising...