1,3,4-Oxadiazole-naphthalene hybrids as potential VEGFR-2 inhibitors: design, synthesis, antiproliferative activity, apoptotic effect, and in silico studies

• Үндсэн зохиолчид: Mohamed Hagras (Зохиогч), Marwa A. Saleh (Зохиогч), Rogy R. Ezz Eldin (Зохиогч), Abdelrahman A. Abuelkhir (Зохиогч), Emad Gamil Khidr (Зохиогч), Ahmed A. El-Husseiny (Зохиогч), Hesham A. El-Mahdy (Зохиогч), Eslam B. Elkaeed (Зохиогч), Ibrahim H. Eissa (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

In the current work, some 1,3,4-oxadiazole-naphthalene hybrids were designed and synthesised as VEGFR-2 inhibitors. The synthesised compounds were evaluated in vitro for their antiproliferative activity against two human cancer cell lines namely, HepG-2 and MCF-7. Compounds that exhibited promising...