LC-MS-based metabolomics in profiling of drug metabolism and bioactivation

• Κύριοι συγγραφείς: Feng Li (Συγγραφέας), Frank J. Gonzalez (Συγγραφέας), Xiaochao Ma (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Elsevier, 2012-04-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Since metabolism significantly affects drug safety and efficacy, determining the metabolic profile of a drug is a critical part of drug development. The application of an LC-MS-based metabolomic approach has gained more widespread use in identifying drug metabolites, developing metabolic maps and le...