LC-MS-based metabolomics in profiling of drug metabolism and bioactivation
Since metabolism significantly affects drug safety and efficacy, determining the metabolic profile of a drug is a critical part of drug development. The application of an LC-MS-based metabolomic approach has gained more widespread use in identifying drug metabolites, developing metabolic maps and le...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Book |
| Published: |
Elsevier,
2012-04-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Since metabolism significantly affects drug safety and efficacy, determining the metabolic profile of a drug is a critical part of drug development. The application of an LC-MS-based metabolomic approach has gained more widespread use in identifying drug metabolites, developing metabolic maps and lending clues to mechanisms of bioactivation. Thus, the LC-MS-based metabolomic approach is a powerful tool for profiling of drug metabolism and bioactivation. |
|---|---|
| Item Description: | 2211-3835 2211-3843 10.1016/j.apsb.2012.02.010 |