Inhibitory effects of bisbenzylisoquinolines on synthesis of the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha

• Main Authors: W. Kim Seow (Author), Kazuhiro Nakamura (Author), Yukio Sugimura (Author), Yukihiro Sugimoto (Author), Yasuyuki Yamada (Author), David P. Fairlie (Author), Y.H. Thong (Author)
• Format: Book
• Published: Hindawi Limited, 1993-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Synthesis of IL-1β and TNFα by human monocytesmacrophages was significantly inhibited by eleven bisbenzylisoquinolines and one half-molecule (benzylisoquinoline), with IC50 values in the μM range. The results indicate that these compounds may have value in the therapy of human diseases where these i...