Inhibitory effects of bisbenzylisoquinolines on synthesis of the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha

• Asıl Yazarlar: W. Kim Seow (Yazar), Kazuhiro Nakamura (Yazar), Yukio Sugimura (Yazar), Yukihiro Sugimoto (Yazar), Yasuyuki Yamada (Yazar), David P. Fairlie (Yazar), Y.H. Thong (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Hindawi Limited, 1993-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Synthesis of IL-1β and TNFα by human monocytesmacrophages was significantly inhibited by eleven bisbenzylisoquinolines and one half-molecule (benzylisoquinoline), with IC50 values in the μM range. The results indicate that these compounds may have value in the therapy of human diseases where these i...