Inhibitory effects of bisbenzylisoquinolines on synthesis of the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha

• Päätekijät: W. Kim Seow (Tekijä), Kazuhiro Nakamura (Tekijä), Yukio Sugimura (Tekijä), Yukihiro Sugimoto (Tekijä), Yasuyuki Yamada (Tekijä), David P. Fairlie (Tekijä), Y.H. Thong (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Hindawi Limited, 1993-01-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Synthesis of IL-1β and TNFα by human monocytesmacrophages was significantly inhibited by eleven bisbenzylisoquinolines and one half-molecule (benzylisoquinoline), with IC50 values in the μM range. The results indicate that these compounds may have value in the therapy of human diseases where these i...