A Cell-Level Systems PK-PD Model to Characterize In Vivo Efficacy of ADCs

• Asıl Yazarlar: Aman P. Singh (Yazar), Leiming Guo (Yazar), Ashwni Verma (Yazar), Gloria Gao-Li Wong (Yazar), Dhaval K. Shah (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2019-02-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Here, we have presented the development of a systems pharmacokinetics-pharmacodynamics (PK-PD) model for antibody-drug conjugates (ADCs), which uses intracellular target occupancy to drive in-vivo efficacy. The model is built based on PK and efficacy data generated using Trastuzumab-Valine-Citrullin...