A Cell-Level Systems PK-PD Model to Characterize In Vivo Efficacy of ADCs
Here, we have presented the development of a systems pharmacokinetics-pharmacodynamics (PK-PD) model for antibody-drug conjugates (ADCs), which uses intracellular target occupancy to drive in-vivo efficacy. The model is built based on PK and efficacy data generated using Trastuzumab-Valine-Citrullin...
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| Hoofdauteurs: | , , , , |
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| Formaat: | Boek |
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MDPI AG,
2019-02-01T00:00:00Z.
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A1234.567 |
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| Kopie 1 | Beschikbaar |