A Cell-Level Systems PK-PD Model to Characterize In Vivo Efficacy of ADCs

Here, we have presented the development of a systems pharmacokinetics-pharmacodynamics (PK-PD) model for antibody-drug conjugates (ADCs), which uses intracellular target occupancy to drive in-vivo efficacy. The model is built based on PK and efficacy data generated using Trastuzumab-Valine-Citrullin...

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Main Authors: Aman P. Singh (Author), Leiming Guo (Author), Ashwni Verma (Author), Gloria Gao-Li Wong (Author), Dhaval K. Shah (Author)
Format: Book
Published: MDPI AG, 2019-02-01T00:00:00Z.
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