Tumor Necrosis Factor-α (TNF-α) Induces Upregulation of RhoA via NF-κB Activation in Cultured Human Bronchial Smooth Muscle Cells

• Asıl Yazarlar: Kumiko Goto (Yazar), Yoshihiko Chiba (Yazar), Hiroyasu Sakai (Yazar), Miwa Misawa (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2009-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Abstract.: RhoA plays an important role in Ca2+ sensitization of bronchial smooth muscle in antigen-induced airway hyperresponsiveness (AHR). Tumor necrosis factor-α (TNF-α), a major proinflammatory cytokine, is capable of inducing AHR, but the mechanisms for this are still unknown. In the present s...