Tumor Necrosis Factor-α (TNF-α) Induces Upregulation of RhoA via NF-κB Activation in Cultured Human Bronchial Smooth Muscle Cells

Abstract.: RhoA plays an important role in Ca2+ sensitization of bronchial smooth muscle in antigen-induced airway hyperresponsiveness (AHR). Tumor necrosis factor-α (TNF-α), a major proinflammatory cytokine, is capable of inducing AHR, but the mechanisms for this are still unknown. In the present s...

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Main Authors: Kumiko Goto (Author), Yoshihiko Chiba (Author), Hiroyasu Sakai (Author), Miwa Misawa (Author)
Format: Book
Published: Elsevier, 2009-01-01T00:00:00Z.
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