Tumor Necrosis Factor-α (TNF-α) Induces Upregulation of RhoA via NF-κB Activation in Cultured Human Bronchial Smooth Muscle Cells

• প্রধান লেখক: Kumiko Goto (লেখক), Yoshihiko Chiba (লেখক), Hiroyasu Sakai (লেখক), Miwa Misawa (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2009-01-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Abstract.: RhoA plays an important role in Ca2+ sensitization of bronchial smooth muscle in antigen-induced airway hyperresponsiveness (AHR). Tumor necrosis factor-α (TNF-α), a major proinflammatory cytokine, is capable of inducing AHR, but the mechanisms for this are still unknown. In the present s...