The Impact of CYP2D6 Genotyping on Tamoxifen Treatment
Tamoxifen remains a cornerstone of treatment for patients with oestrogen-receptor-positive breast cancer. Tamoxifen efficacy depends on the biotransformation, predominantly via the cytochrome P450 2D6 (CYP2D6) isoform, to the active metabolite endoxifen. Both genetic and environmental (drug-induced)...
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MDPI AG,
2010-04-01T00:00:00Z.
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