Inhalable metal-organic framework-mediated cuproptosis combined with PD-L1 checkpoint blockade for lung metastasis synergistic immunotherapy

• Main Authors: Chongzheng Yan (Author), Ying Liu (Author), Guozhi Zhao (Author), Huatian Yang (Author), Huaiyou Lv (Author), Genju Li (Author), Yuhan Li (Author), Yaqing Fu (Author), Fengqin Sun (Author), Yafei Feng (Author), Yizhe Li (Author), Zhongxi Zhao (Author)
• Format: Book
• Published: Elsevier, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cuproptosis shows enormous application prospects in lung metastasis treatment. However, the glycolysis, Cu+ efflux mechanisms, and insufficient lung drug accumulation severely restrict cuproptosis efficacy. Herein, an inhalable poly (2-(N-oxide-N,N-diethylamino)ethyl methacrylate) (OPDEA)-coated cop...